Nephrotoxicity and fungal resistance associated with Amphotericin B

a commented review

Authors

DOI:

https://doi.org/10.24302/sma.v10.3136

Abstract

Introduction: Amphotericin B (AB) is the drug of choice for the treatment of several systemic fungal infections. Despite of its effectiveness and minimum relation to the resistance, AB is toxic to animal cells, in particular to the kidney cells. Objective: To address the aspects of resistance, nephrotoxicity and biomarkers available for the early detection of kidney disease caused by AB. Method: The bibliographic search was performed in online databases. Papers published between 2008-2019, were selected for further analysis and inclusion in the present review. Results: The search resulted in 42 eligible papers which the main findings were: (i) the frequency of resistance to AB appears to be substantial, however, some species should be carefully studied given their diminished susceptibility; (ii) regarding nephrotoxicity, new techniques and methods have promisingly been implemented; and (iii) a novel generation of biomarkers for kidney injury is more specific and sensitive. Conclusion: The adoption of conjugated drug delivery systems is a consistent alternative to minimize nephrotoxicity and fungal resistance. Considering the biomarkers, it is more likely that, instead of a punctual assessment of a single biomarker, a set of biomarkers provides a more thorough comprehension of the aspects related to AB-induced kidney injury. Nonetheless, more clinical studies are necessary for further implementation of such biomarkers in the clinical routine.

Keywords: Amphotericin B. Nephrotoxicity. Acute Kidney Injury. Biomarkers.

Author Biographies

Caroline Berto, Instituto de Saúde Esportiva Estética e Clínica

Especialização em andamento em Biomedicina Estética pelo Instituto de Saúde Esportiva Estética e Clínica. Biomédica pelo Centro Universitário Cenecista de Bento Gonçalves – CNEC. Rio Grande do Sul. Brasil.

Thaís Dalzochio, Centro Universitário CNEC de Bento Gonçalves

Possui graduação em Biomedicina com habilitação em Análises Clínicas pela Universidade Feevale (2010), mestrado (2013) e doutorado (2017) em Qualidade Ambiental, e especialização em Docência Universitária no Século XXI (2019) pela mesma instituição. Atualmente é professora assistente no Centro Universitário CNEC de Bento Gonçalves. Rio Grande do Sul. Brasil.

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Published

2021-02-11

How to Cite

Berto, C., & Dalzochio, T. (2021). Nephrotoxicity and fungal resistance associated with Amphotericin B: a commented review. Saúde E Meio Ambiente: Revista Interdisciplinar, 10, 45–62. https://doi.org/10.24302/sma.v10.3136

Issue

Vol. 10 (2021)

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Artigos

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Copyright (c) 2021 Saúde e meio ambiente: revista interdisciplinar

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